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UID:20260507T200626EDT-8350hm8Jjs@132.216.98.100
DTSTAMP:20260508T000626Z
DESCRIPTION:The Feindel Brain and Mind Seminar Series will advance the visi
 on of Dr. William Feindel (1918–2014)\, Former Director of the Neuro (1972
 –1984)\, to constantly bridge the clinical and research realms. The talks 
 will highlight the latest advances and discoveries in neuropsychology\, co
 gnitive neuroscience\, and neuroimaging.\n\nSpeakers will include scientis
 ts from across The Neuro\, as well as colleagues and collaborators locally
  and from around the world. The series is intended to provide a virtual fo
 rum for scientists and trainees to continue to foster interdisciplinary ex
 changes on the mechanisms\, diagnosis and treatment of brain and cognitive
  disorders.\n\n\nRegister for In-Person\n\nTo watch online\, click here\n
 \nHost: Udunna Anazodo\n\n\nRecovering Brain PET at Reduced Dose: Generati
 ve Models\, Physics Constraints\, and\n	Quantitative Fidelity\n\nAbstract: 
 Brain Positron Emission Tomography (PET) measures molecular processes that
  structural imaging cannot capture\, but its clinical and research utility
  is shaped by an inescapable trade-off between injected radioactivity and 
 image quality. Lowering dose reduces radiation exposure\, which is a prior
 ity for pediatric\, longitudinal\, and repeated-imaging settings\, yet it 
 also amplifies noise\, blurs subtle regional contrast\, and destabilizes t
 he quantitative measures on which diagnosis and kinetic analysis depend. T
 his talk presents research that reframes low-dose brain PET as a coupled s
 ignal recovery and quantification problem rather than a generic denoising 
 task. The talk will trace the progression from SMART-PET\, a self-similari
 ty-aware generative adversarial framework that demonstrated diagnostic-qua
 lity recovery of [¹⁸F]FDG brain PET at 90% dose reduction across epilepsy\
 , frontotemporal dementia\, and healthy cohorts\, to a current physics-gui
 ded generative framework that unifies low-count synthesis and dose recover
 y within a single scanner-aware architecture. Findings indicate that pairi
 ng patient-conditioned diffusion models with projector-based sinogram-spac
 e consistency improves quantitative fidelity and cross-scanner stability o
 ver image-domain methods alone\, and that dual-pathway synthesis enables t
 raining on archives that lack raw sinogram data. Together\, this work char
 ts a path toward clinically usable low-dose brain PET that preserves not j
 ust appearance but measurement.\n\nConfidence Raymond\n\nPhD candidate\, M
 ultimodal Imaging of Neurodegenerative Diseases (MiND) Lab\n	The Neuro\, Mc
 Gill University\n
DTSTART:20260525T170000Z
DTEND:20260525T180000Z
LOCATION:De Grandpré Communications Centre\, The Neuro
SUMMARY:Feindel Brain and Mind Seminar Series: Recovering Brain PET at Redu
 ced Dose: Generative Models\, Physics Constraints\, and Quantitative Fidel
 ity
URL:/spot/channels/event/feindel-brain-and-mind-semina
 r-series-recovering-brain-pet-reduced-dose-generative-models-physics-37285
 7
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