BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20260126T121203EST-6325vuFWo3@132.216.98.100 DTSTAMP:20260126T171203Z DESCRIPTION:\nThe Neuro Epilepsy Day 2026: Epilepsy Across Multiple Scales  \n\nThe Neuro Epilepsy Day will be a full-day program\, exploring epilepsy research and treatment across all scales: molecular\, cellular\, circuit\ , and connectome.\n\n\nRegister Now\n\nTo watch online\, click here\n\n\nC all for Abstracts\n\nWe invite undergraduate\, graduate\, and postdoctoral trainees to submit abstracts for poster presentations at The Neuro Epilep sy Day 2026. \n\nWe encourage abstracts at any stage of a project’s develo pment—from literature reviews and research questions to pilot data and ong oing studies.\n\nSubmission deadline: March 23\, 2026\n\nSubmit Your Abstr act Here\n\nSelected abstracts will be featured in the poster session\, an d five outstanding posters will be invited to give a short oral presentati on during the program.\n\n\n\n \n Programme\n Speakers\n The Pierre Gloor Lect ure\n Location\n Sponsors\n Scientific Committee\n \n\n \n Thursday\, May 28\, 2 026\n\n Preliminary Program \n\n \n \n \n 9:15\n \n Arrival & Registration\n \n \n \n 9:30\n \n Lab Tours\n\n Neuroimaging\, EEG/FMRI\, MEG\,\n \n \n \n 10:45\n \n Wel come and Introduction\n\n Boris Bernhardt\, PhD\n Associate Professor of Neu rology and Neurosurgery\n Epilepsy Group Leader (Research)\, The Neuro\n \n \n \n 11:00\n \n Keynote Lectures\n\n Improving Epilepsy Surgery Planning Using MR Fingerprinting\n\n Irene Wang\, PhD\n Research Director and Staff Scient ist\n Cleveland Clinic Epilepsy Center\n\n Networks\n\n Seok-Jun Hong\, PhD\n Associate Professor of Biomedical Engineering Department\, SKKU\n Sungkyunk wan University - 鶹ýվ\n\n Surgical Approaches and Innovations in FCD\n\n Roy William Dudley\, FRCSC\n Assistant Professor\, Department of Pediatric Surgery\, Department of Neurology & Neurosurgery\n Montreal Child ren's Hospital\n\n Alexander G. Weil\, FRCSC\, FACS\n Associate Professor\, Neurosurgeon\, Researcher\, Director\n University of Montreal - Sainte-Just ine Hospital Research Centre\n\n Jeffery Allan Hall\, FRCSC\n Assistant Prof essor of Neurology and Neurosurgery\n Epilepsy Programme\, Neurosurgery Cli nic\, Brain Tumour Clinic\n\n Sami Obaid\, MD\, PhD\, FRCSC Clinical Assist ant Professor\, Neurosurgeon Department of Surgery\, Faculty of Medicine C entre hospitaliser de l'Université de Montréal\n \n \n \n 1:00\n \n Lunch and Po ster Session\n \n \n \n 2:00\n \n Oral Presentations\n \n \n \n 3:00\n \n Coffee Break \n \n \n \n 3:15\n \n Pierre Gloor Lecture\n\n Brain Mosaicism in Epilepsies and Cortical Malformations\n Stéphanie Baulac\, PhD\n Research director and Grou p Leader\n Inserm and Paris Brain Institute (ICM)\n \n \n \n 4:15\n \n Discussion Panel\n\n Samantha Audrain\, PhD \n\n Alexander Barnett\, PhD \n\n Stéphanie  Baulac\, PhD \n\n Andrea Bernasconi\, MD  \n\n Boris Bernhardt\, PhD \n\n Ne da Ladbon-Bernasconi\, PhD  \n\n Sara Lariviere\, PhD  \n\n Raluca Pana\, MD \, FRCP\, CSCN \n\n Myriam Srour\, MDCM\, PhD \n \n \n \n 5:00\n \n Cocktail Rece ption (onsite)\n \n \n \n \n \n\n \n Speakers\n\n Keynotes:\n\n Irene Wang | Improv ing Epilepsy Surgery Planning Using MR Fingerprinting\n\n Dr. Irene Wang is the Research Director and Full Staff at the Cleveland Clinic Epilepsy Cen ter and an Associate Professor of Neurology at the Cleveland Clinic Lerner College of Medicine. Her research advances surgical treatments for MRI-ne gative epilepsy patients through innovative imaging and neurophysiology te chniques. As a trained biomedical engineer with a strong foundation in cli nical neurophysiology and neuroimaging\, Dr. Wang has pioneered the integr ation of advanced imaging into clinical practice to enhance patient care. She has authored over 120 peer-reviewed papers and serves as Associate Edi tor for Epilepsia. Dr. Wang has received continuous support from the Natio nal Institute of Health and serves as a charter member of the NIH Imaging Technology for Neuroscience study section. Dr. Wang also chairs the MRI Da ta Task Force of the ILAE Big Data Commission and serves on the Imaging Ta sk Force of the ILAE Diagnostic Methods Commission.\n \n Improving Epilepsy Surgery Planning Using MR Fingerprinting\n More details to come...\n\n  \n\n Stéphanie Baulac | Pierre Gloor Lecture\n\n Stéphanie Baulac is a Research Director at Inserm and Group Leader at the Paris Brain Institute (ICM) of the MOSAIC Team « Genetic Mosaicism in Epilepsy and Neurodevelopmental Dis orders » Her team implements a comprehensive translational approach spanni ng from the identification and characterization of somatic mutations in br ain tissues obtained from patients undergoing epilepsy surgery to in-depth functional analysis\, combining functional testing on patient-derived bra in organoids\, and mouse models. \n \n Brain Mosaicism in Epilepsies and Cor tical Malformations\n Focal cortical dysplasia type II (FCDII) is a cortica l malformation causing refractory epilepsy\, resulting from developmental somatic mutations in mTOR pathway genes. To understand how these mutations create a mosaic pattern of affected cells and lead to cortical dyslaminat ion\, we performed comprehensive single-nucleus analyses of surgical sampl es from genetically-characterized FCDII patients. By combining genotyping and transcriptomics at single-cell resolution\, we revealed that mutations predominantly affect glutamatergic neurons and astrocytes\, creating dist inct transcriptional programs in both mutated and non-mutated cells. This mosaicism drives cell-type-specific dysregulation of synaptic and neurodev elopmental pathways that likely contribute to epileptogenesis. Notably\, o ur analysis of cytomegalic cells uncovered pronounced alterations in mitoc hondrial metabolism pathways and cellular senescence. We uncover a signatu re associated with cellular senescence in abnormal FCDII cells and further provide evidence in preclinical FCDII mouse models that senolytic agents could offer a novel therapeutic strategy for this disorder.\n\n  \n\n Seok-J un Hong\n\n Seok-Jun Hong\, PhD is an associate professor in the Department of Biomedical Engineering\, and Brain Science and Engineering at Sungkyun kwan University (SKKU) and also affiliated with the Center for Neuroscienc e Imaging Research\, IBS in S. Korea. Before joining to SKKU\, he was a po stdoctoral research fellow in Child Mind Institute at New York\, working w ith Drs. Michael Milham and Adriana Di Martino\, and before that\, in MNI with Dr. Boris Bernhardt. Dr. Hong’s previous research has focused on adva nced in-vivo multimodal magnetic resonance imaging of typical and atypical brain development (epilepsy and autism)\, especially targeting a large-sc ale brain network organization. Building upon expertise in computer scienc e\, statistics and neuroinformatics\, he has developed original approaches to quantitatively describe connectome principles and its developmental pr ocess in the human brain. These days\, his interest is how to inform biolo gical inductive biases learned from the human brain to build up large-scal e biophysical neural network models.\n\n  \n\n Sami Obaïd | Surgical approac hes and innovations in FCD\n\n - Dr. Sami Obaïd\, M.D.\, Ph.D.\, is a neur osurgeon specializing in epilepsy at the Centre hospitalier de l’Universit é de Montréal (CHUM) and a Clinical Assistant Professor in the Department of Surgery at the Université de Montréal. He is also a principal investiga tor at the CHUM Research Centre (CRCHUM)\, where he leads the ONSET lab. H is surgical practice is dedicated to epilepsy surgery\, and in 2024\, he w as awarded the prestigious FRQS Junior 1 Researcher status. He underwent s pecialized training\, including a fellowship in epilepsy surgery at Yale U niversity and a Ph.D. in structural neuroimaging applied to focal epilepsy . Dr. Obaïd focuses his clinical and scientific activities on the identifi cation\, selection\, presurgical evaluation\, operative and postoperative management of patients with drug-resistant epilepsy through innovative neu roimaging techniques. Recognized early for his contributions to research\, an asteroid was named in his honor: the minor planet Obaïd (21712). He ha s also been named a Distinguished Citizen of Canada for his scientific ach ievements\, listed among the “Top 20 Under 20”\, and one of his articles w as awarded Discovery of the Year 2022 at the CRCHUS. He recently had the h onor of serving as a guest co-speaker alongside astronaut Chris Hadfield\, reflecting the reach of his work and his commitment to science communicat ion. A few months ago\, he also signed the Golden Book of the King of Moro cco in recognition of his academic and scientific accomplishments. At the ONSET laboratory\, Dr. Obaïd currently supervises 22 graduate students and two research assistants\, actively contributing to the training of the ne xt generation of neuroscientists.\n\n  \n\n Roy Dudley | Associate Professor \, 鶹ýվ Health Centre\n\n Roy Dudley MD\, PhD is a an Associat e Professor at 鶹ýվ and a Pediatric Neurosurgeon at the Montr eal Children's Hospital and the Montreal Neurological Hospital. He did his undergraduate studies in Biology and Mathematics at Memorial University o f Newfoundland\, and his PhD in Experimental Medicine at 鶹ýվ and the MN I with the late George Karpati. He returned to Newfoundland for Medical Sc hool and came back to the MNI for Neurosurgery residency under the epileps y surgery tutelage of Jeffery Hall and Andre Olivier. He then did his Pedi atric Neurosurgery Fellowship at the University of Colorado in Denver. Dr. Dudley specializes in epilepsy surgery and is an FRSQ-sponsored clinical investigator with research program focused on optimizing the presurgical e valuation of focal epilepsy patients using advanced neuroimaging and elect rophysiology\, improving the intraoperative localization of malformations of cortical development\, such as focal cortical dysplasia\, and overcomin g the limitation of spatial coverage with SEEG.\n\n Novel Methods in SEEG t o Optimize Epileptogenic Zone Localization and Functional Mapping: Overcom ing the Limitation of Spatial Coverage\n\n Surgical treatment of refractory focal epilepsy can be curative and should be considered as early as possi ble\, particularly in children. In challenging (usually MRI-negative) case s\, an intracerebral investigation via stereo-EEG (SEEG) is often necessar y to localize the epileptogenic zone (EZ). Despite advanced neuroimaging/e lectrophysiology techniques and robotic technology\, the outcome of SEEG h as improved little in 70 years\, the main drawbacks being the often-ill-in formed pre-implantation hypotheses and the sparse coverage of the brain\, resulting in under-sampling or completely missing the EZ and/or its border s\, and suboptimal stimulation for functional mapping. Our ongoing researc h aims to overcome these drawbacks of SEEG by (1) improving the pre-implan tation hypothesis using novel methods in magnetoencephalography (MEG)\, su ch as virtual electrodes\, (2) optimizing SEEG signal analysis via simulta neous MEG/SEEG\, and (3) refining SEEG-based functional mapping via novel analysis (i.e.\, video/SEEG correlates) of spontaneous movements and optim izing the stimulation parameters used to illicit ictal versus normal respo nses.\n\n \n \n\n \n The Pierre Gloor Lecture\n\n The Pierre Gloor Lecture cele brates the life and legacy of Pierre Gloor (1923–2003)\, who joined The Ne uro (Montreal Neurological Institute-Hospital) in 1952 as a fellow in elec troencephalography and neurophysiology. He trained under Wilder Penfield a nd Herbert Jasper and earned his PhD from 鶹ýվ in 1957. Gloor collaborated closely with clinical and research teams at The Neuro in adv ancing the understanding and treatment of epilepsy\, gaining international recognition for his contributions to the field.\n\n Brain Mosaicism in Epi lepsies and Cortical Malformations\n\n Speaker: Stéphanie Baulac\, PhD\n Res earch director and Group Leader\n Inserm and Paris Brain Institute (ICM)\n \n Focal cortical dysplasia type II (FCDII) is a cortical malformation caus ing refractory epilepsy\, resulting from developmental somatic mutations i n mTOR pathway genes. To understand how these mutations create a mosaic pa ttern of affected cells and lead to cortical dyslamination\, we performed comprehensive single-nucleus analyses of surgical samples from genetically -characterized FCDII patients. By combining genotyping and transcriptomics at single-cell resolution\, we revealed that mutations predominantly affe ct glutamatergic neurons and astrocytes\, creating distinct transcriptiona l programs in both mutated and non-mutated cells. This mosaicism drives ce ll-type-specific dysregulation of synaptic and neurodevelopmental pathways that likely contribute to epileptogenesis. Notably\, our analysis of cyto megalic cells uncovered pronounced alterations in mitochondrial metabolism pathways and cellular senescence. We uncover a signature associated with cellular senescence in abnormal FCDII cells and further provide evidence i n preclinical FCDII mouse models that senolytic agents could offer a novel therapeutic strategy for this disorder.\n\n  \n\n \n \n\n \n Location\n\n The M ontreal Neurological Institute and Hospital is at 3801 University Street\, north of Pine Avenue West\, on the 鶹ýվ campus opposite the former Royal Victoria Hospital.\n\n Montreal is served by highway Routes 10 \, 15\, 20 and 40\, and by Greyhound Bus\, Via Rail and the P-E-Trudeau ai rport. In the city\, bus and metro service is provided by the Société de t ransport de Montréal (STM).\n\n Wheelchair access\n\n A wheelchair accessibl e entrance is on University Street north of the main entrance. Another whe elchair accessible entrance is in the loading area behind the building: to enter the loading area\, turn into the driveway south of the main entranc e. Please note\, there is no parking in the loading area.\n\n Parking\n\n Pa rking near the MNI is sometimes difficult. There are parking meters on Uni versity Street and a parking lot north of the main entrance. To enter the lot\, turn right into the driveway toward Molson Stadium.\n\n Information a bout parking fees\n\n Taxi Stand\n\n There is a taxi stand on University Str eet across from the main entrance. You may call a cab from the free taxi p hone in the main lobby near the Security Desk.\n\n Access by Public Transpo rtation (STM website)\n\n Bus\n\n There are four bus stops within walking di stance:\n\n \n Bus 144 stops at Pine Avenue and University Street\n Bus 356 s tops at Sherbrooke Street and University Street (Nightbus)\n Bus 107 stops at Pine Avenue and Docteur Penfield\n Bus 24 stops at Sherbrooke Street and University Street\n \n\n Metro\n\n Take the Metro Green Line to the 鶹ýվ s tation. Walk north on University Street and cross Pine Avenue. The main en trance is on the right\, past the flags.\n\n Jeanne Timmins Amphitheatre\n \n \n Enter the main lobby\, turn left\, and go down the hallway to the end. \n Turn right and go down the second hallway until you see another hallway on the left.\n This hallway leads to the Jeanne Timmins Foyer.\n On your rig ht are the Jeanne Timmins Amphitheatre entrance doors.\n \n \n\n \n Sponsors  \n \n\n \n Scientific Committee\n\n Sam Audrain\n\n Alexander Barnett\n\n Boris Bernhardt\n\n Sara Larivière\n\n Raluca Pana\n\n Debbie Rashcovsky\n\n Myriam Srour\n\n  \n\n \n \n\n DTSTART:20260528T131500Z DTEND:20260528T210000Z LOCATION:Jeanne Timmins Amphitheatre\, The Neuro SUMMARY:The Neuro Epilepsy Day 2026: Epilepsy Across Multiple Scales URL:/research/channels/event/neuro-epilepsy-day-2026-e pilepsy-across-multiple-scales-368975 END:VEVENT END:VCALENDAR