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UID:20260307T155624EST-3874ivvcAN@132.216.98.100
DTSTAMP:20260307T205624Z
DESCRIPTION:\nSupported by the generosity of the Killam Trusts\, The Neuro'
 s Killam Seminar Series invites outstanding guest speakers whose research 
 is of interest to the scientific community at The Neuro and Â鶹´«Ã½ÍøÕ¾ Univers
 ity.\n\n\nRegister Now\n\nTo watch online\, click here\n\nHost: Heidi McBr
 ide\n\n\nStudying Memory for Natural Events Across Multiple Timescales\n\n
 Abstract: Oxygen deprivation (hypoxia) and excess (hyperoxia) are both tox
 ic to humans. Oxygen deprivation contributes to 3 of the 5 leading causes 
 of mortality in developed nations -- heart attack\, stroke\, and respirato
 ry failure. On the other hand\, hyperoxia is toxic to nearly all organisms
  and contributes to the pathology of ischemia-reperfusion injury\, mitocho
 ndrial disease and hyperoxic lung injury. However\, the molecular mechanis
 ms underlying hypoxia and hyperoxia toxicity remain unknown. By decipherin
 g these mechanisms\, we strive to nominate novel therapeutic candidates. O
 ur recent work highlights such mechanisms of hyperoxia toxicity and the cy
 cle of damage caused by destabilization of specific iron-containing protei
 n complexes. While small molecules and biologics are the most common forms
  of therapy\, we believe we have uncovered a new mode of treating metaboli
 c disorders. We now hope to extend our findings to additional inborn error
 s of metabolism\, as well as more common metabolic disorders\, including a
 ging and age-associated damage.\n\nIsha Jain\n\nAssociate Professor\, Bioc
 hemistry and Biophysics\, UCSF\, USA\n\n \n\nIsha received her undergradua
 te degree in Chemical and Physical Biology from Harvard University. There\
 , she worked in the lab of Erin O’Shea on bacterial chromosome segregation
 . Subsequently\, she joined the Harvard-MIT Program in Health Sciences and
  Technology. During her PhD\, she worked in the   labs of Vamsi Mootha and
  Warren Zapol\, where she discovered that hypoxia could serve as a therapy
  for mitochondrial disorders. This work led to a Phase 1 clinical trial. I
 sha began as a UCSF Sandler Faculty Fellow and then joined the Gladstone I
 nstitutes and UCSF in 2021. She has received the NIH Early Independence Gr
 ant\, Searle Scholar Award\, Klingenstein-Simons Award\, Mallinckrodt Awar
 d\, TRDRP New Investigator Award\, AFAR Junior Faculty Award\, Hillblom St
 art-Up Grant\, Keck Medical Research Grant\, and Arc Innovation Investigat
 or Award.\n
DTSTART:20260317T200000Z
DTEND:20260317T210000Z
LOCATION:de Grandpre Communications Centre\, The Neuro\, Montreal Neurologi
 cal Institute\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Killam Seminar Series: Turning the Oxygen and Vitamin Dials
URL:/neuro/channels/event/killam-seminar-series-turnin
 g-oxygen-and-vitamin-dials-371565
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