BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4//
BEGIN:VEVENT
UID:20250919T210357EDT-6914NsjEPb@132.216.98.100
DTSTAMP:20250920T010357Z
DESCRIPTION:\nGrâce à la générosité des fiducies Killam\, Le Neuro convoque
  lors d’une série de séminaires des conférenciers d’exception dont les tra
 vaux passionnent ses chercheurs et ceux de l’Université Â鶹´«Ã½ÍøÕ¾. \n\n\nPour
  assister en personne\, inscrivez-vous ici\n\nPour regarder via Vimeo\, cl
 iquez ici\n\n\nFranck Polleux\n\nProfesseur de neurosciences\, Université 
 de Columbia\n\nHôte: eric.shoubridge [at] mcgill.ca (Eric Shoubridge )\n\n
 Abstract: Two of the most striking distinguishing features of human cortic
 al pyramidal neurons (CPNs) are: (1) human CPNs receive significantly more
  excitatory and inhibitory synapses than any other mammalian species inclu
 ding non-human primates and (2) synaptic development is strikingly neoteni
 c in humans\, taking years to reach maturation compared to weeks or months
  in other mammalian species. Our lab identified two human-specific gene du
 plications called SRGAP2B/C which\, by inhibiting all known functions of t
 he post-synaptic ancestral protein SRGAP2A\, leads to slower (neotenic) ra
 tes of excitatory (E) and inhibitory (I) synaptic maturation and increased
  E and I synapse number. We also demonstrated that this increased density 
 of E synapses in layer 2/3 cortical pyramidal neurons (CPNs) originates fr
 om increased cortico-cortical connections\, leading to changes in the codi
 ng properties of these neurons in vivo and improved behavioral performance
  in a sensory discrimination task in mice humanized for SRGAP2C expression
 . I will summarize recent results demonstrating (1) the function of human-
 specific genes SRGAP2B/C as critical modifiers of synaptic development in 
 human neurons using xenotransplantation and (2) that SRGAP2B/C also act as
  human-specific disease modifiers in the context of neurodevelopmental dis
 orders.\n
DTSTART:20241112T210000Z
DTEND:20241112T220000Z
LOCATION:de Grandpre Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Killam Seminar Series: Human-Specific Modifiers of Cortical Circuit
 s Evolution
URL:/neuro/fr/channels/event/killam-seminar-series-hum
 an-specific-modifiers-cortical-circuits-evolution-359673
END:VEVENT
END:VCALENDAR