BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20260407T124425EDT-3619uSkTGl@132.216.98.100 DTSTAMP:20260407T164425Z DESCRIPTION:\nThe Neuro Epilepsy Day 2026: Epilepsy Across Multiple Scales  \n\nThe Neuro Epilepsy Day will be a full-day program\, exploring epilepsy research and treatment across all scales: molecular\, cellular\, circuit\ , and connectome.\n\n\nRegister Now\n\nTo watch online\, click here\n\n\nC all for Abstracts\n\nWe invite undergraduate\, graduate\, and postdoctoral trainees to submit abstracts for poster presentations at The Neuro Epilep sy Day 2026. \n\nWe encourage abstracts at any stage of a project’s develo pment—from literature reviews and research questions to pilot data and ong oing studies.\n\nSubmission deadline: March 30\, 2026\n\nTo submit an abst ract\, click here\n\nSelected abstracts will be featured in the poster ses sion\, and five outstanding posters will be invited to give a short oral p resentation during the program.\n\n\n\n \n Programme\n Speakers\n The Pierre G loor Lecture\n Location\n Sponsors\n Scientific Committee\n \n\n \n Thursday\, M ay 28\, 2026\n\n Preliminary Program \n\n \n \n \n 9:15\n \n Arrival & Registrati on\n \n \n \n 9:30\n \n Lab Tours\n\n Neuroimaging\, EEG/FMRI\, MEG\,\n \n \n \n 10:4 5\n \n Welcome and Introduction\n\n Boris Bernhardt\, PhD\n Associate Professo r of Neurology and Neurosurgery\n Epilepsy Group Leader (Research)\, The Ne uro\n \n \n \n 11:00\n \n Keynote Lectures\n\n Improving Epilepsy Surgery Plannin g Using MR Fingerprinting\n\n Irene Wang\, PhD\n Research Director and Staff Scientist\n Cleveland Clinic Epilepsy Center\n\n Networks\n\n Seok-Jun Hong\ , PhD\n Associate Professor of Biomedical Engineering Department\, SKKU\n Su ngkyunkwan University - 鶹ýվ\n\n Surgical Approaches and Innov ations in FCD\n\n Roy William Dudley\, FRCSC\n Assistant Professor\, Departm ent of Pediatric Surgery\, Department of Neurology & Neurosurgery\n Montrea l Children's Hospital\n\n Alexander G. Weil\, FRCSC\, FACS\n Associate Profe ssor\, Neurosurgeon\, Researcher\, Director\n University of Montreal - Sain te-Justine Hospital Research Centre\n\n Jeffery Allan Hall\, FRCSC\n Assista nt Professor of Neurology and Neurosurgery\n Epilepsy Programme\, Neurosurg ery Clinic\, Brain Tumour Clinic\n\n Sami Obaid\, MD\, PhD\, FRCSC Clinical Assistant Professor\, Neurosurgeon Department of Surgery\, Faculty of Med icine Centre hospitaliser de l'Université de Montréal\n \n \n \n 1:00\n \n Lunch and Poster Session\n \n \n \n 2:00\n \n Oral Presentations\n \n \n \n 3:00\n \n Coffe e Break\n \n \n \n 3:15\n \n Pierre Gloor Lecture\n\n Brain Mosaicism in Epilepsi es and Cortical Malformations\n Stéphanie Baulac\, PhD\n Research director a nd Group Leader\n Inserm and Paris Brain Institute (ICM)\n \n \n \n 4:15\n \n Dis cussion Panel\n\n Samantha Audrain\, PhD \n\n Alexander Barnett\, PhD \n\n St éphanie Baulac\, PhD \n\n Andrea Bernasconi\, MD  \n\n Boris Bernhardt\, PhD  \n\n Neda Ladbon-Bernasconi\, PhD  \n\n Sara Lariviere\, PhD  \n\n Raluca Pa na\, MD\, FRCP\, CSCN \n\n Myriam Srour\, MDCM\, PhD \n \n \n \n 5:00\n \n Cockta il Reception (onsite)\n \n \n \n \n \n\n \n Speakers\n\n Keynotes:\n\n Irene Wang |  Improving Epilepsy Surgery Planning Using MR Fingerprinting\n\n Dr. Irene Wang is the Research Director and Full Staff at the Cleveland Clinic Epile psy Center and an Associate Professor of Neurology at the Cleveland Clinic Lerner College of Medicine. Her research advances surgical treatments for MRI-negative epilepsy patients through innovative imaging and neurophysio logy techniques. As a trained biomedical engineer with a strong foundation in clinical neurophysiology and neuroimaging\, Dr. Wang has pioneered the integration of advanced imaging into clinical practice to enhance patient care. She has authored over 120 peer-reviewed papers and serves as Associ ate Editor for Epilepsia. Dr. Wang has received continuous support from th e National Institute of Health and serves as a charter member of the NIH I maging Technology for Neuroscience study section. Dr. Wang also chairs the MRI Data Task Force of the ILAE Big Data Commission and serves on the Ima ging Task Force of the ILAE Diagnostic Methods Commission.\n \n Improving Ep ilepsy Surgery Planning Using MR Fingerprinting\n\n This talk will focus on MR Fingerprinting (MRF)\, a novel quantitative MRI technique that enables simultaneous acquisition of multiple tissue parameters within a single\, time-efficient acquisition\, providing a comprehensive multiparametric cha racterization of brain tissue properties. The talk will include clinical e xamples and studies demonstrating the added value of MRF for detection and subtype characterization of focal cortical dysplasia\, including cases wi th subtle or nonlesional findings on conventional MRI. The talk will furth er explore the potential of MRF-derived tissue metrics to inform in vivo e pileptogenicity in more complex malformations of cortical development\, su ch as periventricular nodular heterotopia and polymicrogyria. Together\, t hese examples illustrate how MRF can enhance presurgical localization\, op timize SEEG implantation\, and improve prognostication for epilepsy surger y candidates.\n\n  \n\n Stéphanie Baulac | Pierre Gloor Lecture\n\n Stéphanie Baulac is a Research Director at Inserm and Group Leader at the Paris Bra in Institute (ICM) of the MOSAIC Team « Genetic Mosaicism in Epilepsy and Neurodevelopmental Disorders » Her team implements a comprehensive transla tional approach spanning from the identification and characterization of s omatic mutations in brain tissues obtained from patients undergoing epilep sy surgery to in-depth functional analysis\, combining functional testing on patient-derived brain organoids\, and mouse models. \n \n Brain Mosaicism in Epilepsies and Cortical Malformations\n Focal cortical dysplasia type I I (FCDII) is a cortical malformation causing refractory epilepsy\, resulti ng from developmental somatic mutations in mTOR pathway genes. To understa nd how these mutations create a mosaic pattern of affected cells and lead to cortical dyslamination\, we performed comprehensive single-nucleus anal yses of surgical samples from genetically-characterized FCDII patients. By combining genotyping and transcriptomics at single-cell resolution\, we r evealed that mutations predominantly affect glutamatergic neurons and astr ocytes\, creating distinct transcriptional programs in both mutated and no n-mutated cells. This mosaicism drives cell-type-specific dysregulation of synaptic and neurodevelopmental pathways that likely contribute to epilep togenesis. Notably\, our analysis of cytomegalic cells uncovered pronounce d alterations in mitochondrial metabolism pathways and cellular senescence . We uncover a signature associated with cellular senescence in abnormal F CDII cells and further provide evidence in preclinical FCDII mouse models that senolytic agents could offer a novel therapeutic strategy for this di sorder.\n\n  \n\n Seok-Jun Hong\n\n - Seok-Jun Hong\, PhD is an associate pr ofessor in the Department of Biomedical Engineering\, and Brain Science an d Engineering at Sungkyunkwan University (SKKU) and also affiliated with t he Center for Neuroscience Imaging Research\, IBS in S. Korea. Before join ing to SKKU\, he was a postdoctoral research fellow in Child Mind Institut e at New York\, working with Drs. Michael Milham and Adriana Di Martino\, and before that\, in MNI with Dr. Boris Bernhardt. Dr. Hong’s previous res earch has focused on advanced in-vivo multimodal magnetic resonance imagin g of typical and atypical brain development (epilepsy and autism)\, especi ally targeting a large-scale brain network organization. Building upon exp ertise in computer science\, statistics and neuroinformatics\, he has deve loped original approaches to quantitatively describe connectome principles and its developmental process in the human brain. These days\, his intere st is how to inform biological inductive biases learned from the human bra in to build up large-scale biophysical neural network models.\n \n Advanced Brain Imaging in Neurodevelopmental Disorders: Semantic Mapping\, Multimod al DBS Modeling\, and MRI Lesion Synthesis\n The recent integration of adva nced computational neuroimaging with AI and biophysical modeling is cataly zing a paradigmatic shift in the clinical management of children with neur odevelopmental disorders. This evolution spans the entire translational co ntinuum—from early diagnosis and mechanistic understanding to personalized therapeutic interventions. In this talk\, I will discuss three distinct y et interconnected proof-of-concept cases that illustrate the power of thes e approaches. First\, to uncover the neurobiological principles underlying clinical behaviors in Autism Spectrum Disorder (ASD)\, I will discuss our recent findings using naturalistic movie-viewing fMRI to construct high-d imensional semantic maps. I will demonstrate how these maps reveal age-dep endent distortions in ASD\, their correlation with symptom severity\, and their utility in parsing phenotypic heterogeneity into distinct neurobiolo gical subtypes. Second\, I will present ongoing research regarding Deep Br ain Stimulation (DBS) in epilepsy. We demonstrate how multimodal MRI can b e leveraged to predict DBS efficacy by modeling the structural and functio nal pathways associated with the seizure focus. Notably\, we investigate t he specific network mechanisms that dictate the success or failure of thes e neuromodulatory interventions\, providing a framework for optimized surg ical targeting. Third\, I will explore the emerging role of Generative AI in medical imaging\, specifically through the lens of MRI lesion synthesis . This section highlights how synthetic data can augment epilepsy research and improve diagnostic inference\, particularly in clinical scenarios whe re high-quality data is sparse. Finally\, I will conclude by outlining how these advanced computational frameworks are accelerating the realization of precision medicine in neurodevelopmental conditions and offer my outloo k on the future landscape of the field.\n\n  \n\n Sami Obaïd | Surgical appr oaches and innovations in FCD\n\n - Dr. Sami Obaïd\, M.D.\, Ph.D.\, is a n eurosurgeon specializing in epilepsy at the Centre hospitalier de l’Univer sité de Montréal (CHUM) and a Clinical Assistant Professor in the Departme nt of Surgery at the Université de Montréal. He is also a principal invest igator at the CHUM Research Centre (CRCHUM)\, where he leads the ONSET lab . His surgical practice is dedicated to epilepsy surgery\, and in 2024\, h e was awarded the prestigious FRQS Junior 1 Researcher status. He underwen t specialized training\, including a fellowship in epilepsy surgery at Yal e University and a Ph.D. in structural neuroimaging applied to focal epile psy. Dr. Obaïd focuses his clinical and scientific activities on the ident ification\, selection\, presurgical evaluation\, operative and postoperati ve management of patients with drug-resistant epilepsy through innovative neuroimaging techniques. Recognized early for his contributions to researc h\, an asteroid was named in his honor: the minor planet Obaïd (21712). He has also been named a Distinguished Citizen of Canada for his scientific achievements\, listed among the “Top 20 Under 20”\, and one of his article s was awarded Discovery of the Year 2022 at the CRCHUS. He recently had th e honor of serving as a guest co-speaker alongside astronaut Chris Hadfiel d\, reflecting the reach of his work and his commitment to science communi cation. A few months ago\, he also signed the Golden Book of the King of M orocco in recognition of his academic and scientific accomplishments. At t he ONSET laboratory\, Dr. Obaïd currently supervises 22 graduate students and two research assistants\, actively contributing to the training of the next generation of neuroscientists.\n\n  \n\n Roy Dudley | Associate Profes sor\, 鶹ýվ Health Centre\n\n - Roy Dudley MD\, PhD is a an As sociate Professor at 鶹ýվ and a Pediatric Neurosurgeon at the Montreal Children's Hospital and the Montreal Neurological Hospital. He d id his undergraduate studies in Biology and Mathematics at Memorial Univer sity of Newfoundland\, and his PhD in Experimental Medicine at 鶹ýվ and the MNI with the late George Karpati. He returned to Newfoundland for Medi cal School and came back to the MNI for Neurosurgery residency under the e pilepsy surgery tutelage of Jeffery Hall and Andre Olivier. He then did hi s Pediatric Neurosurgery Fellowship at the University of Colorado in Denve r. Dr. Dudley specializes in epilepsy surgery and is an FRSQ-sponsored cli nical investigator with research program focused on optimizing the presurg ical evaluation of focal epilepsy patients using advanced neuroimaging and electrophysiology\, improving the intraoperative localization of malforma tions of cortical development\, such as focal cortical dysplasia\, and ove rcoming the limitation of spatial coverage with SEEG.\n\n Novel Methods in SEEG to Optimize Epileptogenic Zone Localization and Functional Mapping: O vercoming the Limitation of Spatial Coverage\n\n Surgical treatment of refr actory focal epilepsy can be curative and should be considered as early as possible\, particularly in children. In challenging (usually MRI-negative ) cases\, an intracerebral investigation via stereo-EEG (SEEG) is often ne cessary to localize the epileptogenic zone (EZ). Despite advanced neuroima ging/electrophysiology techniques and robotic technology\, the outcome of SEEG has improved little in 70 years\, the main drawbacks being the often- ill-informed pre-implantation hypotheses and the sparse coverage of the br ain\, resulting in under-sampling or completely missing the EZ and/or its borders\, and suboptimal stimulation for functional mapping. Our ongoing r esearch aims to overcome these drawbacks of SEEG by (1) improving the pre- implantation hypothesis using novel methods in magnetoencephalography (MEG )\, such as virtual electrodes\, (2) optimizing SEEG signal analysis via s imultaneous MEG/SEEG\, and (3) refining SEEG-based functional mapping via novel analysis (i.e.\, video/SEEG correlates) of spontaneous movements and optimizing the stimulation parameters used to illicit ictal versus normal responses.\n\n  \n\n Jeffery Allan Hall | Epilepsy Neurosurgeon MNI-H\, Ass ociate Professor 鶹ýվ\n\n - Dr. Hall completed undergraduate and graduat e degrees in Neuropsychology and Cognitive Neuroscience before medical tra ining. His Neurosurgical Residency and Fellowship in the Surgery of Epilep sy were completed at 鶹ýվ/MNI-H. He has been an Attending on the Epileps y Service at the MNI-H for more than 20 years. Dr. Hall is fascinated by t he introduction of new technology to foster novel treatment options. Over the past decade\, he has become interested in the strengths and limitation s of Radio-Frequency Thermo-Coagulation via implanted electrodes (SEEG) as a potential therapeutic intervention.\n\n Radio-Frequency Thermo-Coagulati on via Stereoelectroencephalography\n\n This presentation will briefly revi ew the history of Stereoelectroencephalography (SEEG) as initially propose d and the relevant advances with new materials and techniques. For more th an two decades\, commercial electrodes have been used to create lesions vi a Radio-Frequency Thermo-Coagulation (RF-TC). Lesion generation will be de monstrated ex vivo. Factors which influence lesion size and geometry will be discussed. Patient cases will be shown with the view that some patholog ies underlying intractable epilepsy may be more amenable to RF-TC.\n\n \n \n \n \n The Pierre Gloor Lecture\n\n The Pierre Gloor Lecture celebrates the li fe and legacy of Pierre Gloor (1923–2003)\, who joined The Neuro (Montreal Neurological Institute-Hospital) in 1952 as a fellow in electroencephalog raphy and neurophysiology. He trained under Wilder Penfield and Herbert Ja sper and earned his PhD from 鶹ýվ in 1957. Gloor collaborated closely with clinical and research teams at The Neuro in advancing the un derstanding and treatment of epilepsy\, gaining international recognition for his contributions to the field.\n\n Brain Mosaicism in Epilepsies and C ortical Malformations\n\n Speaker: Stéphanie Baulac\, PhD\n Research directo r and Group Leader\n Inserm and Paris Brain Institute (ICM)\n\n Focal cortic al dysplasia type II (FCDII) is a cortical malformation causing refractory epilepsy\, resulting from developmental somatic mutations in mTOR pathway genes. To understand how these mutations create a mosaic pattern of affec ted cells and lead to cortical dyslamination\, we performed comprehensive single-nucleus analyses of surgical samples from genetically-characterized FCDII patients. By combining genotyping and transcriptomics at single-cel l resolution\, we revealed that mutations predominantly affect glutamaterg ic neurons and astrocytes\, creating distinct transcriptional programs in both mutated and non-mutated cells. This mosaicism drives cell-type-specif ic dysregulation of synaptic and neurodevelopmental pathways that likely c ontribute to epileptogenesis. Notably\, our analysis of cytomegalic cells uncovered pronounced alterations in mitochondrial metabolism pathways and cellular senescence. We uncover a signature associated with cellular senes cence in abnormal FCDII cells and further provide evidence in preclinical FCDII mouse models that senolytic agents could offer a novel therapeutic s trategy for this disorder.\n\n  \n\n \n \n\n \n Location\n\n The Montreal Neurol ogical Institute and Hospital is at 3801 University Street\, north of Pine Avenue West\, on the 鶹ýվ campus opposite the former Royal V ictoria Hospital.\n\n Montreal is served by highway Routes 10\, 15\, 20 and 40\, and by Greyhound Bus\, Via Rail and the P-E-Trudeau airport. In the city\, bus and metro service is provided by the Société de transport de Mo ntréal (STM).\n\n Wheelchair access\n\n A wheelchair accessible entrance is on University Street north of the main entrance. Another wheelchair access ible entrance is in the loading area behind the building: to enter the loa ding area\, turn into the driveway south of the main entrance. Please note \, there is no parking in the loading area.\n\n Parking\n\n Parking near the MNI is sometimes difficult. There are parking meters on University Street and a parking lot north of the main entrance. To enter the lot\, turn rig ht into the driveway toward Molson Stadium.\n\n Information about parking f ees\n\n Taxi Stand\n\n There is a taxi stand on University Street across fro m the main entrance. You may call a cab from the free taxi phone in the ma in lobby near the Security Desk.\n\n Access by Public Transportation (STM w ebsite)\n\n Bus\n\n There are four bus stops within walking distance:\n\n \n B us 144 stops at Pine Avenue and University Street\n Bus 356 stops at Sherbr ooke Street and University Street (Nightbus)\n Bus 107 stops at Pine Avenue and Docteur Penfield\n Bus 24 stops at Sherbrooke Street and University St reet\n \n\n Metro\n\n Take the Metro Green Line to the 鶹ýվ station. Walk n orth on University Street and cross Pine Avenue. The main entrance is on t he right\, past the flags.\n\n Jeanne Timmins Amphitheatre\n\n \n Enter the m ain lobby\, turn left\, and go down the hallway to the end.\n Turn right an d go down the second hallway until you see another hallway on the left.\n T his hallway leads to the Jeanne Timmins Foyer.\n On your right are the Jean ne Timmins Amphitheatre entrance doors.\n \n \n\n \n Sponsors \n\n \n \n\n \n Scie ntific Committee\n\n Sam Audrain\n\n Alexander Barnett\n\n Boris Bernhardt\n \n Sara Larivière\n\n Raluca Pana\n\n Debbie Rashcovsky\n\n Myriam Srour\n\n   \n\n \n \n\n DTSTART:20260528T131500Z DTEND:20260528T210000Z LOCATION:Jeanne Timmins Amphitheatre\, The Neuro SUMMARY:The Neuro Epilepsy Day 2026: Epilepsy Across Multiple Scales URL:/epi-biostat-occh/channels/event/neuro-epilepsy-da y-2026-epilepsy-across-multiple-scales-368975 END:VEVENT END:VCALENDAR