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Photocatalytic methodologies have become a cornerstone of synthetic chemistry, offering new ways to access high-value intermediates under mild reaction conditions. Due to the widespread demand for more efficient photocatalytic approaches, constant innovation is required to reach the desired reactivity, selectivity, and stability, while making these methods sustainable and accessible. For this reason, during the last decade, the Li lab has reported numerous tools that provide solutions to existing challenges on diverse fronts, including but not limited to: the development of new reagents to access facile and streamlined functionalization reactions, the in-depth study of new catalytic pathways for the exploration of diversified reactivities, and the design of new and accessible devices that allow for accelerated optimization of reaction conditions.

In this talk, we will focus on the area of homogeneous photocatalysis, identifying areas of opportunity, and current efforts to address these challenges while providing standardized solutions. Some of the published works to discuss during the talk will provide insight into first, developing a series of bench-stable photocleavable reagents for the perfluoroalkylation of electron-rich aromatics under metal-free and redox- and pH-neutral conditions. Second, the stepwise discovery of simple triarylamines as catalytic electron donors in Electron Donor-Acceptor (EDA) complexes. And finally, the design of a 3D-printed photoreactor compatible with High-Throughput Experimentation (HTE) for the discovery and optimization of novel reactions promoted by visible light.

Bio:

Durbis J. Castillo Pazos did his bachelor鈥檚 degree in chemistry at the Autonomous University of the State of Mexico. As an undergrad he had the opportunity to participate in several internships across Europe and North America, where he gained experience in nanotechnology, peptide synthesis, structural biology, and computational chemistry. After finishing his degree in 2017, Durbis spent one year working as a consultant for the National Autonomous University of Mexico using QSAR for regulatory affairs.

In 2018, Durbis started his doctoral studies at 麻豆传媒网站 under the supervision of Prof. Chao-Jun Li, working in the development of novel synthetic methodologies mediated by light, being funded through the Vanier, CONACYT, and Tomlinson scholarships. During his PhD, he secured an internship at the pharmaceutical company Merck, where he gained expertise in DNA-Encoded Libraries (DEL). After defending his thesis in the Fall of 2024, he joined Merck as a Senior Scientist in the Discovery Chemistry department, where he currently works at the High-Throughput Experimentation group to accelerate the impactful discovery of new medicines and treatments.