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DTSTAMP:20260512T201041Z
DESCRIPTION:A unifying neuropathological spectrum underlies medial temporal
  lobe epilepsy\n\nDr. Larissa Kraus\, postdoctoral researcher\, Cembrowski
  lab\, UBC\n\nAbstract: Medial temporal lobe epilepsy (mTLE)\, characteriz
 ed by seizures arising from the hippocampus\, is the most common form of f
 ocal epilepsy. Discrete histopathological subtypes\, based upon coarse reg
 ional patterns of hippocampal neuronal loss\, are the field-standard frame
 work for interpreting mTLE-associated neuropathology. Here\, using single-
 cell spatial transcriptomics to profile >1.1 million cells from the hippoc
 ampus of 18 individuals\, we examine molecular-cellular alterations in mTL
 E and reassess this discrete-subtype framework. Our data reveal previously
  unresolved signatures of molecular-cellular vulnerability in mTLE\, inclu
 ding neuronal degeneration\, glial remodeling\, and significant network re
 organization. We also identify a pathological spectrum — resolvable at the
  level of molecules\, cells\, and regions — that accounts for supposedly d
 iscrete histopathological subtypes and is described by therapeutically-rel
 evant cellular programs. Ultimately\, our work reveals new principles unde
 rlying human hippocampal organization and dysregulation in mTLE\, identifi
 es therapeutic targets conserved across the mTLE spectrum\, and provides t
 he most comprehensive histopathological atlas of mTLE to date.\n\n\n	Zoom l
 ink: https://mcgill.zoom.us/j/81367247906\n	Website: https://www.singlecell
 club.ca/\n	Chair: Kate Bornais\n
DTSTART:20260513T130000Z
DTEND:20260513T140000Z
SUMMARY:Larissa Kraus -Single Cell Club May 2026 Seminar 
URL:/centre-montreal/channels/event/larissa-kraus-sing
 le-cell-club-may-2026-seminar-372873
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