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DTSTAMP:20251129T153112Z
DESCRIPTION:The Annual George Karpati Lecture honours a world-renowned neur
 ologist and clinician-scientist who dedicated his remarkable career to The
  Neuro. Dr. Karpati was celebrated for advancing the diagnosis\, treatment
 \, and understanding of neuromuscular diseases\, especially muscular dystr
 ophy. Each year\, his colleagues host this lecture to highlight recent pro
 gress in neuromuscular research and care\, paying tribute to a beloved fri
 end\, mentor\, and scientific leader.\n\n\nRegistration coming soon.\n\n\n
 The Era of Bespoke Therapies for Genetic Neuromuscular Diseases\n\nLecture
  Abstract: Myology has been an indispensable centerpiece in our expanding 
 understanding of basic biology\, cellular physiology\, and genetics over c
 enturies. It has also been a constant partner in development of techniques
  to study cellular biology\, histopathology\, and disease pathogenesis. Ho
 wever\, many primary disorders of skeletal muscle remain recalcitrant. Wit
 h the recent advent of DNA- and RNA-directed therapies\, a decades-long vi
 sion of treating patients with rare neuromuscular diseases seems within re
 ach\, although many barriers remain to be overcome. This presentation will
  give an overview of monogenic neuromuscular disorders from a physician-sc
 ientist viewpoint and provide a few concrete examples of approaches in the
  laboratory to study disease pathomechanisms\, to identify therapeutic tar
 gets\, and to develop bespoke/precision therapies for these rare diseases.
 \n\nPayam Mohassel\n\n\n\nDr. Mohassel is a physician scientist who specia
 lizes in myopathies\, muscular dystrophies\, and other hereditary neuromus
 cular disorders. He is also the co-director of the Johns Hopkins Myositis 
 Center and a myopathologist. Dr. Mohassel obtained his medical degree from
  the Johns Hopkins University School of Medicine\, where he remained for a
  medical internship\, residency training in neurology\, and clinical fello
 wship training in neuromuscular medicine. He then joined the National Inst
 itute of Neurological Disorders and Stroke Neurogenetics branch as a clini
 cal research fellow under the mentorship of Prof. Carsten Bonnemann for 8 
 years\, before returning to Johns Hopkins department of Neurology as facul
 ty. Dr. Mohassel’s research focuses on translational studies in neurogenet
 ic\, neuromuscular disorders\, and it spans gene discovery efforts\, mecha
 nistic studies to identify therapeutic targets\, and early phase intervent
 ional clinical trials for rare neuromuscular diseases.\n
DTSTART:20260224T210000Z
DTEND:20260224T230000Z
LOCATION:Jeanne Timmins Amphitheatre\, The Neuro
SUMMARY:George Karpati Lecture: The Era of Bespoke Therapies for Genetic Ne
 uromuscular Diseases
URL:/campusoutaouais/channels/event/george-karpati-lec
 ture-era-bespoke-therapies-genetic-neuromuscular-diseases-367516
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